Twentyone Hotel
Via Cola Di Rienzo 23, Rome, 00195, Italy
Book online now. Rates from EUR57.
Book online or call
US: 888-205-7322
UK: 0808 145-3778
EU: +1 469-610-3608
View all photos in gallery
Book online now
Book Now
or call 888-205-7322
Rates from EUR57
1 Room With 2 Adults Change Search
Check Rates
Twentyone Hotel is a modern 4-star hotel located on one of Rome’s finest shopping streets. Castel Sant’Angelo as well as the historic centre is only a 10-minute walk away.

Perfectly situated on Via Cola di Rienzo, this boutique hotel of luxury allows guests to explore the stylish Prati district, home of Saint Peter’s Basilica and the Vatican, with ease. Bus and metro links are found close by.

Guests of Twentyone Hotel will enjoy its ultra-modern interiors and minimalist décor. Each of the spacious guestrooms comes with an LCD satellite TV. Guests can also take advantage of free Wi-Fi access in the lounge.

The Friendly staff of Twentyone will be pleased to arrange transfers, trips and guided tours and for guests.

Hotel Services and Facilities

Free WiFi Free parking Free breakfast

Hotel facilities

  • 24 hour front desk
  • Airport Transportation
  • Concierge
  • Restaurant
  • Room Service
  • Wheelchair Access
  • Contactless check-in and check-out are available
  • Lounge/Bar

Guest reviews

Click here to leave your opinion >>
stayed in July, 2009
Guest Score 7.5 out of 10
The location. The clean and new decoration of the hotel.
No 24h room service; no restaurant or living room. The breakfast was only continental.Some of the employers had difficulty to speak english.


What are the check-in and check-out times at Twentyone Hotel?
The guests can check in from 14:00. Check-out time is 11:00.
What is the nearest airport to Twentyone Hotel?
Rome, Italy (CIA-Ciampino) is located 9.85mi from the property.
Is there airport transportation available at Twentyone Hotel?
Guests in need of traveling to/from the airport may arrange transportation with the reception.
Is Twentyone Hotel wheelchair accessible?
The hotel has wheelchair accessibility throughout its grounds.
Is there a lounge or bar at Twentyone Hotell?
Guests may find a large selection of both alcoholic and non-alcoholic beverages at the in-house bar/lounge.
Is the front desk open 24 hours?
Our helpful 24-hour front desk is ready to assist you with any inquiry.
Is there a concierge available at Twentyone Hotel?
A friendly and helpful concierge is always ready to assist with any inquiries.
Are there restaurants nearby or on-site?
Looking for a place to eat? The property offers at least one full-service restaurant.
Will room service be provided?
Room service can be arranged for guests staying at the hotel.

How to book

Making reservations for Twentyone Hotel on this website is a secure and straightforward process. To check the nightly rates of Twentyone Hotel, simply begin by selecting the desired dates/length of stay and click the "Check Rates" button. Comparison and decisions can then be made with the display of pricing information for each style of guest room. Information regarding room features and amenities is provided in the center of the screen. Having made the decision for dates, room style, and rates, simply locate and click on the "Book Now" button on the right hand side of the screen.


After making this selection you will be transferred to a "Complete Your Booking" form where various information will be requested in order to reserve your room at Twentyone Hotel. The "Details of Your Stay" will be displayed for your review so that you can ensure all information regarding your visit is acceptable and understood. After reviewing the details, proceed by filling in the information requested in the "Guest Details" section. Answer the few basic questions required. Please be sure to look over all supplied answers so that important details such as name and email address are spelled correctly. Upon completing this, simply select the "Complete Reservation" button to finish booking your room at Twentyone Hotel. The use of a secure commerce server ensures that all personal data such as credit card information is secure and encoded into a non-usable form.

View all photos in gallery
Guest reviews
...clean and new decoration of the hotel...
Overall score: 7.5
(out of 10) Based on 1 votes
Click here to leave your opinion

Area information

    • Rome, Italy (CIA-Ciampino) - 9.85 mi
    • Rome, Italy (FCO-Leonardo Da Vinci) - 13.69 mi
    • Museum of the Souls of Purgatory - 0.39 mi
    • Castel Sant'Angelo Museum - 0.47 mi
    • Explora il Museo dei Bambini di Roma - 0.48 mi
    • Altemps Museum - 0.60 mi